In March 17th, 2015, the deputy general manager Yuan Xiaolu, director Shi Yulong and some others had invented the high content of nicotinamide induced by new characteristics synthesis of nitrile hydratase, and had applied for a patent. In July 8th, 2015, the application was announced. The invention discloses a method for producing microbial catalysis of nicotinamide, based on synergy theory, proposed a novel two element composite nitrile hydratase, the composite enzyme is produced by the combination culture of bacillus subtilis and rhodococcus. With the help of high substrate specificity, thermal stability of bacillus subtilis and rhodococcus’ stronger promoter action, then gain microbial nitrile hydratase with new characteristics (high stereoselectivity, regioselectivity and high concentration of substrate and product). At the same time add a certain concentration solvent into the reaction system to accelerate the reaction, the synthesis method is simple and efficient, environmentally and friendly, the purity and yield of the product can reach more than 99% and it is suitable for large scale industrial production.
In March 17th, 2015, the chairman Liu Shanhe, the director Qian Qian and some others had invented a method, using immobilized cells transform the nicotinonitrile into nicotinamide, and applied for a patent. In July 8th, 2015, the application was announced. The invention provides a method to use immobilized cells to transform nicotinonitrile into nicotinamide, including tobacco nitrile hydratase producing strain of cultured cells, immobilized cell preparation, immobilized cell biotransformation transforming nicotinonitrile to product nicotinamide-hydration reaction and nicotinamide extraction process. In the process of the invention, the immobilized cell is used as the catalyst, so the biological catalyst can be repeatedly used and the production cost is reduced, the process is simplified, and the yield of the product is greatly improved. The method has simple process and it is suitable for large scale industrial production. The product has high conversion rate and high purity.
In August 24th, 2015, Wei Yongfei, Fang Hongxin and some others had invented a process gas heater for the preparation of vitamin B3, and applied for a patent, in February 24th, 2016, the application was announced. The invention discloses a process gas heater for the preparation of vitamin B3, which comprises a cylinder body, two tube plates and a plurality of heat exchange tubes and a baffle plate, the two port of the cylinder body are respectively connected with the two piece tube plate fixedly, the upper side of the cylinder body is provided with a steam inlet, the lower part of the other side of the cylinder body is set the steam outlet, the baffle plate is fixedly arranged on both sides of the inner wall of the barrel body, the baffle plate between the alternately arranged equidistantly, heat exchange tube inlet is arranged in the tube plate close to the steam outlet, the air outlet of heat exchange pipe is arranged in a block or a baffle plate. The invention is effective for process gas of heating, and ensures the hydration reaction successfully of the mixed gas containing 3- cyano and water.
In August 27th, 2015, Wei Chenhong, Tang Xianlong and some others had invented an improved solution evaporation tower for the preparation of vitamin B3, and applied for a patent, in January 27th, 2016, the application was announced. The invention discloses an improved solution evaporation tower which is used for preparing vitamin B3, which comprises an upper tower body, a cone connecting cylinder, a mist removing device, a feeding pipe, a sealing head, a flange and a heater. The invention improves the nicotinamide’s potency by evaporation to remove the water of nicotinamide solution, the heat increases evaporation rate and production efficiency, at the same time save the energy.